
They warn users of such drugs may think treatment services are geared towards crack or heroin and not seek help.
The NHS clinic, based at the Chelsea and Westminster Hospital in south-west London, has two years' funding.
It is staffed by doctors, nurses, drug workers, psychologists and HIV workers.
Dr Owen Bowden-Jones, founder of the clinic, said: "The health risks associated with excessive use of club drugs are under-estimated by many people.
"Little is known about the potential problems of the newer drugs."
Dr Bowden-Jones said existing services focused on alcohol, heroin and crack cocaine use.
"Many people experiencing club drug problems do not see current treatment services as well equipped to help them," he added.
"As a result they do not seek treatment."
The new clinic was piloted for five months and received more than 70 referrals.
It has the capacity to see nine new patients every day.
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